Impact of bromodomain‐containing protein 4 (BRD4) and intestine‐specific homeobox (ISX) expression on the prognosis of patients with hepatocellular carcinoma' for better clarity

Autor: Shih Hsien Hsu, Kai Ting Chuang, Shen-Nien Wang, Li Ting Wang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Cancer Research
Cell Cycle Proteins
Metastasis
Epigenesis
Genetic
0302 clinical medicine
p300-CBP Transcription Factors
HCC
Child
Research Articles
RC254-282
Cancer Biology
Aged
80 and over
Liver Neoplasms
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Middle Aged
Prognosis
Gene Expression Regulation
Neoplastic
Survival Rate
Real-time polymerase chain reaction
Oncology
PCAF
030220 oncology & carcinogenesis
Hepatocellular carcinoma
BRD4
Female
Liver cancer
Research Article
Adult
Carcinoma
Hepatocellular
Adolescent
03 medical and health sciences
Young Adult
Cell Line
Tumor
medicine
Biomarkers
Tumor
Hepatectomy
Humans
Radiology
Nuclear Medicine and imaging
Lung cancer
Aged
Retrospective Studies
Homeodomain Proteins
ISX
business.industry
Gene Expression Profiling
Cancer
medicine.disease
Intestine-Specific Homeobox
030104 developmental biology
Cancer research
business
Follow-Up Studies
Transcription Factors
Zdroj: Cancer Medicine, Vol 10, Iss 16, Pp 5545-5556 (2021)
Cancer Medicine
ISSN: 2045-7634
Popis: Epigenetic regulation is important for cancer tumor metastasis and progression, including lung and liver cancer. However, the mechanism of epigenetic regulation in liver cancer leaves much to be discussed. According to a previous study, p300/CBP‐associated factor (PCAF) mediated epithelial–mesenchymal transition (EMT) and promotes cancer metastasis by recruiting intestine‐specific homeobox (ISX) and bromodomain‐containing protein 4 (BRD4) in lung cancer. To figure out whether the three genes are also expressed in patients with hepatocellular carcinoma (HCC) or not, and their correlation with patients’ outcome, BRD4, PCAF, and ISX messenger RNA (mRNA) expression levels in 377 patients with HCC were investigated using quantitative polymerase chain reaction and confocal fluorescence imaging. The correlation of the gene expression (PCAF, ISX, and BRD4) in liver cancer is also being investigated. Here, we show that the mRNA expression of PCAF, BRD4, and ISX in 377 paired specimens from patients with HCC, and the adjacent normal tissues exhibited a tumor‐specific expression pattern, highly correlated with disease pathogenesis, patient survival time, progression stage, and poor prognosis. The results show that ISX and BRD4 can potentially be a target for improving the survival rate.
ISX and BRD4 can potentially be a target for improving the survival rate.
Databáze: OpenAIRE
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