Sporadic Autonomic Dysregulation and Death Associated with Excessive Serotonin Autoinhibition
| Autor: | Elisabetta Coppi, Mumna Al Banchaabouchi, Enrica Audero, Renato Corradetti, Cornelius Gross, Boris Mlinar, Antonio Caprioli, Tiziana Rossetti |
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| Rok vydání: | 2008 |
| Předmět: |
Bradycardia
Serotonin medicine.medical_specialty Postmortem studies Sympathetic Nervous System Pyridines Mice Transgenic Motor Activity Biology Autonomic Nervous System Synaptic Transmission Sudden death Piperazines Body Temperature Electrocardiography Mice chemistry.chemical_compound Heart Rate Internal medicine medicine Animals Homeostasis Humans Autonomic dysregulation Neurotransmitter Autoreceptors Cause of death Feedback Physiological Neurons Multidisciplinary Tryptophan Infant Neural Inhibition Sudden infant death syndrome Endocrinology chemistry Doxycycline Receptor Serotonin 5-HT1A Raphe Nuclei Serotonin Antagonists medicine.symptom Sudden Infant Death |
| Zdroj: | Science. 321:130-133 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Sudden infant death syndrome is the leading cause of death in the postneonatal period in developed countries. Postmortem studies show alterations in serotonin neurons in the brainstem of such infants. However, the mechanism by which altered serotonin homeostasis might cause sudden death is unknown. We investigated the consequences of altering the autoinhibitory capacity of serotonin neurons with the reversible overexpression of serotonin 1A autoreceptors in transgenic mice. Overexpressing mice exhibited sporadic bradycardia and hypothermia that occurred during a limited developmental period and frequently progressed to death. Moreover, overexpressing mice failed to activate autonomic target organs in response to environmental challenges. These findings show that excessive serotonin autoinhibition is a risk factor for catastrophic autonomic dysregulation and provide a mechanism for a role of altered serotonin homeostasis in sudden infant death syndrome. |
| Databáze: | OpenAIRE |
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