Risk of anomalies as a function of level of elevated maternal serum α-fetoprotein
| Autor: | Arie Drugan, Mark P. Johnson, Avihai Reichler, Mordechai Bardicef, Mark I. Evans, Roderick F. Hume, Nelson B. Isada |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Risk
medicine.medical_specialty Population Autopsy Oligohydramnios Congenital Abnormalities Pregnancy Internal medicine medicine Humans Neural Tube Defects education Retrospective Studies education.field_of_study Fetus Neural tube defect business.industry Obstetrics Incidence (epidemiology) Neural tube Obstetrics and Gynecology Retrospective cohort study medicine.disease medicine.anatomical_structure Endocrinology Female alpha-Fetoproteins business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 171:1052-1055 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(13)90033-8 |
| Popis: | Objective: Most neural tube defects risks, are not actual but mathematic extrapolations. We sought to evaluate this risk and to compare actual performance. Study Design: This was a retrospective study of a referral population with elevated maternal serum α-fetoprotein results between 1987 and 1992. Ultrasonography results, delivery records, and autopsy results were compared with entry levels of maternal serum α-fetoprotein, and the percentage of fetal anomalies detected in this study was evaluated. Results: A total of 773 patients with elevated maternal serum α-fetoprotein levels were evaluated. There was a progressive increase in the incidence of anomalies as a direct function of the level of the maternal serum AFP, varying from 3.4% at a level of 2.5 to 40.3% at a level>7.0. Conclusion: Data from this study support the correlation of maternal serum AFP levels with the risk of neural tube defect and ventral wall defects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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