Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia
| Autor: | Nina V. Kraguljac, David White, Jan A. den Hollander, Adrienne C. Lahti, Kathy B. Avsar, Meredith A. Reid |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Magnetic Resonance Spectroscopy Glutamine Glutamic Acid Substantia nigra Neuropsychological Tests Creatine Article Young Adult chemistry.chemical_compound Nuclear magnetic resonance Neuroimaging Dopamine mental disorders medicine Humans Choline Magnetization transfer Biological Psychiatry Analysis of Variance Aspartic Acid Glutamate receptor Middle Aged medicine.disease Magnetic Resonance Imaging Substantia Nigra Psychiatry and Mental health nervous system chemistry Schizophrenia Female Protons Psychology Neuroscience medicine.drug |
| Zdroj: | Schizophrenia Research. 147:348-354 |
| ISSN: | 0920-9964 |
| Popis: | Background Converging evidence in schizophrenia points to disruption of the dopamine and glutamate neurotransmitter systems in the pathophysiology of the disorder. Dopamine is produced in the substantia nigra, but few neuroimaging studies have specifically targeted this structure. In fact, no studies of the substantia nigra in schizophrenia have used proton magnetic resonance spectroscopy (MRS). We sought to demonstrate the feasibility of acquiring single-voxel MRS measurements at 3 T from the substantia nigra and to determine which metabolites could be reliably quantified in schizophrenia patients and healthy controls. Methods We used a turbo spin echo sequence with magnetization transfer contrast to visualize the substantia nigra and single-voxel proton MRS to quantify levels of N -acetylaspartate, glutamate and glutamine (Glx), and choline in the left substantia nigra of 35 people with schizophrenia and 22 healthy controls. Results We obtained spectra from the substantia nigra and quantified neurometabolites in both groups. We found no differences in levels of N -acetylaspartate/creatine, Glx/creatine, or choline/creatine between the groups. We found a significant correlation between Glx/creatine and overall cognitive performance, measured with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), in controls but not patients, a difference that was statistically significant. Conclusions Our study demonstrates the feasibility of obtaining single-voxel MRS data from the substantia nigra in schizophrenia. Such measurements may prove useful in understanding the biochemistry underlying cellular function in a region implicated in the pathophysiology of schizophrenia. |
| Databáze: | OpenAIRE |
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