Thyroxine impregnated chitosan-based dressings stimulate angiogenesis and support fast wounds healing in rats: Potential clinical candidates
| Autor: | Saimoon Tehseen, Mustehsan Bashir, Muhammad Yar, Aqif Anwar Chaudhry, Lubna Shahzadi, Mubashra Zehra, Ihtesham Ur Rehman, Azra Mehmood |
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| Rok vydání: | 2019 |
| Předmět: |
Angiogenesis
Neovascularization Physiologic macromolecular substances 02 engineering and technology Biochemistry Chorioallantoic Membrane Chitosan 03 medical and health sciences chemistry.chemical_compound Structural Biology Spectroscopy Fourier Transform Infrared Animals Molecular Biology Cells Cultured 030304 developmental biology 0303 health sciences Wound Healing integumentary system Chemistry technology industry and agriculture General Medicine equipment and supplies 021001 nanoscience & nanotechnology Bandages Rats carbohydrates (lipids) Thyroxine Membrane Chitosan membrane Wound closure Full thickness 0210 nano-technology Wound healing Porosity Biomedical engineering |
| Zdroj: | International journal of biological macromolecules. 160 |
| ISSN: | 1879-0003 |
| Popis: | This research paper demonstrates efficacy of chitosan and thyroxine loaded chitosan (CS) dressings for their angiogenic and wound healing potential. The dressings were prepared by freeze gelation method. Thyroxine was loaded by physical adsorption into chitosan membranes. The porosity was analyzed by scanning electron microscopy (SEM) and chemical structures were investigated by Fourier transform infra-red spectroscopy (FTIR). Cell culture studies showed materials were non-toxic and chorioallantoic membranes assay (CAM) confirmed that the thyroxine loaded chitosan stimulated angiogenesis much higher than simple chitosan dressings. In addition, thyroxine loaded dressings showed excellent wound healing potential when tested on full thickness rats wounds. A good epithelialization was obtained along with robust wound closure. Overall, as compared to chitosan, thyroxine containing membranes showed high level of angiogenesis and fast wound healing. |
| Databáze: | OpenAIRE |
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