Soluble CD40L in patients with morbid obesity: significant reduction after bariatric surgery
| Autor: | Guntram Schernthaner, S. Kriwanek, Renate Koppensteiner, K. Krzyzanowska, H.‐P. Kopp |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Gastroplasty medicine.medical_treatment CD40 Ligand Clinical Biochemistry Biochemistry Body Mass Index Insulin resistance Weight loss Weight Loss medicine Humans Insulin Clinical significance Postoperative Period Platelet activation Myocardial infarction Prospective cohort study Chemokine CCL2 business.industry General Medicine Middle Aged medicine.disease Thrombosis Obesity Morbid Surgery C-Reactive Protein Solubility Linear Models Female Inflammation Mediators Insulin Resistance medicine.symptom business Biomarkers |
| Zdroj: | European Journal of Clinical Investigation. 36:395-401 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.2006.01649.x |
| Popis: | Background Morbid obesity is associated with increased cardiovascular morbidity and mortality. Recent studies suggest that soluble CD40 Ligand (sCD40L) may play a pathogenetic role in atherothrombotic complications in cardiovascular disease as well as in inflammation and thrombosis. As morbid obesity is closely associated with chronic inflammation and insulin resistance (IR), it was of interest to study sCD40L in patients with morbid obesity before and after massive weight loss induced by bariatric surgery. Patients and methods A total of 34 patients (mean age 40 ± 12 years) with morbid obesity were studied before and 27·2 months after bariatric surgery. High sensitivity assays were used to measure concentrations of fasting sCD40L, monocyte-chemoattractant-protein-1 (MCP-1) and high-sensitive C-reactive protein (hsCRP). To investigate the associations of concentration changes of the parameters studied, differences between pre- and post-operative data were assessed and tested by univariate and multivariate linear regression analysis. Results After a mean weight loss of 33·1 ± 18·4 kg, circulating sCD40L decreased significantly from (3·7 ± 1·5) ng mL−1 to (2·2 ± 0·7) ng mL−1, (P |
| Databáze: | OpenAIRE |
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