Galectin-1 expression in oral squamous cell carcinoma: An immunohistochemical study
| Autor: | GL Pradeep, Aarti Mahajan, Sajda Khan Gajdhar, Vaibhavi Salunkhe, Rekha Patil, Nilima Prakash |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.drug_class Angiogenesis Context (language use) Monoclonal antibody Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Galectin-1 Medicine metastasis General Dentistry business.industry 030206 dentistry medicine.disease invasion Staining oral squamous cell carcinoma stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Cervical lymph nodes 030220 oncology & carcinogenesis immunohistochemistry Immunohistochemistry Original Article business |
| Zdroj: | Journal of Oral and Maxillofacial Pathology : JOMFP |
| ISSN: | 1998-393X 0973-029X |
| Popis: | Context: Oral squamous cell carcinoma (OSCC) of the head and neck are a heterogeneous group of neoplasms with an increasing rate of mortality and morbidity. OSCCs are characterized by a high degree of local invasiveness and metastasis to cervical lymph nodes but show a lower rate of distant metastasis. Galectin-1 (Gal-1), a β-galactoside-binding lectin, is known to regulate tumor cell growth, angiogenesis, mediate cell-cell or cell-extracellular matrix adhesion and promote cancer cell migration. Aims: This study aims to evaluate the Gal-1 expression in different clinical stages and histological grades of OSCC. Settings and Design: Forty histopathologically diagnosed cases of OSCC, including 16 cases of well-differentiated, 18 moderately differentiated and 6 poorly differentiated carcinomas, were included in the study group. Materials and Methods: The samples were subjected to staining using primary mouse monoclonal antibodies against Gal-1 and visualized using polymer-HRP detection system. Statistical Analysis: The nonparametric Mann–Whitney U-test and Kruskal–Wallis ANOVA test were used for the statistical analysis. Results: Gal-1 expression was higher in advanced stages of OSCC, and the results were statistically significant. Immunoexpression of Gal-1 increased with advancing histological grades of OSCC with statistically significant results. Conclusion: Gal-1 plays an important role in invasion, metastasis and as a prognostic marker. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|