Vascular smooth muscle cell c-Fos is critical for foam cell formation and atherosclerosis

Autor:	Guolin Miao, Xi Zhao, Siu-Lung Chan, Lijun Zhang, Yaohua Li, Yuke Zhang, Beibei Wang
Rok vydání:	2022
Předmět:	Lipoproteins LDL Mice Endocrinology Apolipoproteins E Endocrinology Diabetes and Metabolism Myocytes Smooth Muscle Animals Humans Atherosclerosis Scavenger Receptors Class E Muscle Smooth Vascular Foam Cells Rats
Zdroj:	Metabolism: clinical and experimental. 132
ISSN:	1532-8600
Popis:	Hyperlipidemia-induced vascular smooth muscle cell (VSMC)-derived foam cell formation is considered a crucial event in the development of atherosclerosis. Since c-Fos emerges as a key modulator of lipid metabolism, we investigated whether c-Fos plays a role in hyperlipidemia-induced VSMC-derived foam cell formation and atherosclerosis.c-Fos expression was observed in VSMCs in atherosclerotic plaques from patients and western diet-fed atherosclerosis-prone LDLROur study demonstrates a fundamental role of mtROS/c-Fos/LOX-1 signaling pathway in promoting oxLDL uptake and VSMC-derived foam cell formation during atherosclerosis. c-Fos may represent a promising therapeutic target amenable to clinical translation in the future.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e582dbaf4c74328a8b03e5f070be09 https://pubmed.ncbi.nlm.nih.gov/35513168 Zobrazit plný text záznamu Full Text from ScienceDirect