MOG Spectrum Disorders and Role of MOG-Antibodies in Clinical Practice
| Autor: | Eva-Maria Hennes, Christian Lechner, Kevin Rostasy, Matthias Baumann |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Encephalomyelitis Myelitis Transverse myelitis Myelin oligodendrocyte glycoprotein 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Humans Optic neuritis Child Autoantibodies biology business.industry Multiple sclerosis Encephalomyelitis Acute Disseminated General Medicine medicine.disease nervous system diseases 030104 developmental biology nervous system Child Preschool Pediatrics Perinatology and Child Health Immunology Acute disseminated encephalomyelitis biology.protein Myelin-Oligodendrocyte Glycoprotein Neurology (clinical) Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Neuropediatrics. 49:003-011 |
| ISSN: | 1439-1899 0174-304X |
| DOI: | 10.1055/s-0037-1604404 |
| Popis: | Myelin oligodendrocyte glycoprotein (MOG) antibodies (abs) are present in one third of all children with an acute demyelinating syndrome (ADS). MOG-abs can be found in acute disseminated encephalomyelitis (ADEM), transverse myelitis, isolated optic neuritis (ON), or recurrent demyelinating diseases, such as multiphasic neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 (AQP4) abs or multiphasic ADEM (MDEM), but rarely in children who subsequently develop multiple sclerosis (MS). The presence of MOG-abs is age dependent with the highest seropositivity rates found in young children and an episode of ADEM, whereas older children with MOG-abs present with ON, myelitis, or brainstem symptoms. MOG-abs, initially thought to be associated with a benign disease course, are found in a substantial proportion of children with relapsing episodes associated with high and persisting MOG-ab titers. This review describes, in particular, the increasing spectrum of phenotypes associated with MOG-abs with a focus on clinical characteristics, radiological features, and therapeutic aspects. |
| Databáze: | OpenAIRE |
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