Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis
| Autor: | Amanda D. Caulfield, Eric T. Harvill, Longhuan Ma, Kalyan K. Dewan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Bordetella pertussis Epidemiology Whooping Cough 030106 microbiology 030231 tropical medicine PRN Infectious and parasitic diseases RC109-216 Vaccine antigen whole-cell vaccine waning immunity pertactin 03 medical and health sciences respiratory infections 0302 clinical medicine Antigen medicine Humans Pertactin-Deficient Bordetella pertussis Vaccine-Driven Evolution and Reemergence of Pertussis Virulence Factors Bordetella bacteria Child Whooping cough Pertussis Vaccine reemergence biology Rapid expansion pertussis Antibody titer vaccines medicine.disease biology.organism_classification vaccine-driven evolution Virology United States respiratory tract diseases Infectious Diseases acellular vaccine pertactin deficient Synopsis Medicine Acellular vaccines Pertactin antibody titers Bacterial Outer Membrane Proteins |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 27, Iss 6, Pp 1561-1566 (2021) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and potential return of what was once the major killer of children. The discovery that most circulating B. pertussis strains in the United States have acquired new and independent disruptive mutations in PRN is compelling evidence of strong selective pressure. However, the other 4 antigens included in acellular vaccines do not appear to be selected against so rapidly. We consider 3 aspects of PRN that distinguish it from other vaccine antigens, which might, individually or collectively, explain why only this antigen is being precipitously eliminated. An understanding of the increase in PRN-deficient strains should provide useful information for the current search for new protective antigens and provide broader lessons for the design of improved subunit vaccines. |
| Databáze: | OpenAIRE |
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