A rat mutation producing demyelination (dmy) maps to chromosome 17
| Autor: | Norihide Yokoi, Tadao Serikawa, Takashi Kuramoto, E Goñalons Sintes, Constantino Sotelo, Jean-Louis Guénet, J Cantó Martorell |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Genes Recessive Locus (genetics) Breeding Biology Rats Sprague-Dawley Mice Myelin Genetics Homologous chromosome medicine Animals Humans Polymorphic Microsatellite Marker Gene Myelin Sheath Lumbosacral Region Chromosome Mapping Chromosome Phenotype Molecular biology Rats Chromosome 17 (human) medicine.anatomical_structure Spinal Cord Mutation Female Demyelinating Diseases Microsatellite Repeats |
| Zdroj: | Mammalian Genome. 7:890-894 |
| ISSN: | 1432-1777 0938-8990 |
| DOI: | 10.1007/s003359900263 |
| Popis: | A recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation, was discovered in a partially inbred rat colony. Analysis of the segregation patterns of a set of polymorphic microsatellite markers in two inter-strain crosses allowed the mapping of this autosomal recessive mutation to rat Chromosome (Chr) 17, very close to the prolactin (Prl) locus, in a region homologous to human Chr 6p21.2-22.3 and mouse Chr 13. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human. |
| Databáze: | OpenAIRE |
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