The Effects of Chronic Resveratrol Treatment on Vascular Responsiveness of Streptozotocin-Induced Diabetic Rats

Autor: Coskun Silan
Rok vydání: 2008
Předmět:
Blood Glucose
Male
vascular reactivity
endocrine system diseases
Muscle Relaxation
Vasodilator Agents
Pharmaceutical Science
Resveratrol
medicine.disease_cause
Antioxidants
Muscle
Smooth
Vascular
chemistry.chemical_compound
Stilbenes
Vasoconstrictor Agents
diabetes
Anti-Inflammatory Agents
Non-Steroidal
food and beverages
General Medicine
Malondialdehyde
medicine.anatomical_structure
Sodium nitroprusside
Muscle Contraction
medicine.drug
Nitroprusside
medicine.medical_specialty
Endothelium
Diabetes Mellitus
Experimental
Thoracic Arteries
Diabetes mellitus
medicine.artery
Internal medicine
medicine
Animals
Rats
Wistar
Pharmacology
Aorta
Dose-Response Relationship
Drug
business.industry
Body Weight
medicine.disease
Streptozotocin
Rats
Oxidative Stress
Endocrinology
chemistry
Blood Vessels
Endothelium
Vascular
business
Oxidative stress
Zdroj: Biological and Pharmaceutical Bulletin. 31:897-902
ISSN: 1347-5215
0918-6158
Popis: Silan, Coskun/0000-0002-8352-6571; silan, coskun/0000-0002-8352-6571 WOS: 000256182500023 PubMed: 18451515 Deficiency in the vasorelaxant capacity is a result of an oxidative stress in diabetic animals and seems to be an etiological factor of vascular complications of diabetes. The present study was designed to examine whether resveratrol (RSV), a polyphenolic compound which is naturally present in grape and red wine, has a protective effect on diabetic aorta. Resveratrol (5 mg/kg/d, i.p.) was administered for 42 d to streptozotocin (STZ) (60 mg/kg) induced diabetic rats. Loss of weight, hyperglycemia, and elevated levels of plasma malondialdehyde (NIDA) were observed in diabetic rats. Resveratrol treatment was significantly effective for these metabolic and biochemical abnormalities. The contractile responses of the aorta were recorded. Compared with control subjects, the aorta showed significantly enhanced contractile responses to noradrenaline (NA), but not to potassium chloride (KCI), in diabetic rats. Treatment of diabetic rats with resveratrol significantly reversed the increases in responsiveness and sensitivity of aorta to noradrenaline. In diabetic aorta, the relaxation response to acetylcholine (Ach) was found to be significantly decreased compared with control subjects, and resveratrol treatment reversed this; no such change was observed in the relaxation response to sodium nitroprusside (SNP). These results indicated that resveratrol significantly improved not only glucose metabolism and oxidative injury but also impaired vascular responses in streptozotocin induced diabetic rats.
Databáze: OpenAIRE
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