Elementary immunology: Na+ as a regulator of immunity
| Autor: | Jens Titze, Patrick Neubert, Matthias Gebhard, Agnes Schröder, Valentin Schatz, Jonathan Jantsch, Dominik N. Müller, Katrina J. Binger, Friedrich C. Luft |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
T cell Skin salt storage Regulator T cells Immune Cell Function Inflammation Review Biology Sodium Chloride T-Lymphocytes Regulatory Local Na+ availability Cutaneous Elimination 03 medical and health sciences Mice 0302 clinical medicine Immune system Immunity medicine Macrophage Animals Humans Pediatrics Perinatology and Child Health Immune cell function and activation Macrophages Sodium 3. Good health 030104 developmental biology medicine.anatomical_structure Nephrology Pediatrics Perinatology and Child Health Immunology medicine.symptom 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Pediatric Nephrology (Berlin, Germany) |
| ISSN: | 1432-198X 0931-041X |
| Popis: | The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases with age, inflammation and infection. This increased local Na+ availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na+ availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na+ levels bears broad therapeutic potential: increasing local Na+ availability may help in treating infections, while lowering tissue Na+ levels may be used to treat, for example, autoimmune and cardiovascular diseases. |
| Databáze: | OpenAIRE |
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