Accuracy of a clinical PET/CT vs. a preclinical μPET system for monitoring treatment effects in tumour xenografts
| Autor: | Karin Palmowski, Moritz Palmowski, F. A. Verburg, Oliver Winz, Felix M. Mottaghy, Florian F. Behrendt, Anne Rix, Jessica Bzyl |
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| Přispěvatelé: | RS: NUTRIM - R1 - Metabolic Syndrome, Beeldvorming, MUMC+: DA BV Medische staf (6) |
| Rok vydání: | 2013 |
| Předmět: |
Treatment response
Indoles Mice Nude Angiogenesis Inhibitors Antineoplastic Agents Quantitative accuracy Multimodal Imaging Sensitivity and Specificity Imaging phantom Preclinical research Mice Untreated control Fluorodeoxyglucose F18 Small animal Cell Line Tumor Sunitinib Medicine Animals Radiology Nuclear Medicine and imaging Pyrroles PET-CT business.industry Reproducibility of Results General Medicine Equipment Design Neoplasms Experimental Equipment Failure Analysis Treatment Outcome Positron-Emission Tomography Female Animal studies Drug Monitoring Radiopharmaceuticals Nuclear medicine business Tomography X-Ray Computed |
| Zdroj: | European Journal of Radiology, 82(8), 1318-1324. Elsevier Ireland Ltd |
| ISSN: | 1872-7727 0720-048X |
| Popis: | PURPOSE: Small animal imaging is of growing importance for preclinical research and drug development. Tumour xenografts implanted in mice can be visualized with a clinical PET/CT (cPET); however, it is unclear whether early treatment effects can be monitored. Thus, we investigated the accuracy of a cPET versus a preclinical muPET using (18)F-FDG for assessing early treatment effects. MATERIALS AND METHODS: The spatial resolution and the quantitative accuracy of a clinical and preclinical PET were evaluated in phantom experiments. To investigate the sensitivity for assessing treatment response, A431 tumour xenografts were implanted in nude mice. Glucose metabolism was measured in untreated controls and in two therapy groups (either one or four days of antiangiogenic treatment). Data was validated by gamma-counting of explanted tissues. RESULTS: In phantom experiments, cPET enabled reliable separation of boreholes>/=5mm whereas muPET visualized boreholes>/=2mm. In animal studies, muPET provided significantly higher tumour-to-muscle ratios for untreated control tumours than cPET (3.41+/-0.87 vs. 1.60+/-.0.28, respectively; p/=5mm at an advanced time-point of treatment. For imaging smaller tumours or for the sensitive assessment of very early therapy effects, muPET should be preferred. |
| Databáze: | OpenAIRE |
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