Correction to: Rev1 wbdR tagged vaccines against Brucella ovis
| Autor: | Pilar M. Muñoz, Miriam Salvador-Bescós, M. J. de Miguel, Amaia Zúñiga-Ripa, Maite Iriarte, Raquel Conde-Álvarez, Ignacio Moriyón, Estrella Martínez-Gómez, Beatriz Aragón-Aranda |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Brucella ovis 040301 veterinary sciences Brucella Vaccine Biology Vaccines Attenuated Brucellosis 0403 veterinary science Mice 03 medical and health sciences Polysaccharides Animals GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Mice Inbred BALB C lcsh:Veterinary medicine General Veterinary Vacuna Published Erratum Correction Amino Sugars Brucelosis 04 agricultural and veterinary sciences Brucella Virology 030104 developmental biology lcsh:SF600-1100 Female |
| Zdroj: | Veterinary Research, Vol 51, Iss 1, Pp 1-1 (2020) Veterinary Research |
| ISSN: | 1297-9716 |
| DOI: | 10.1186/s13567-020-00752-6 |
| Popis: | Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine. |
| Databáze: | OpenAIRE |
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