Effect of probiotics on aspirin-induced gastric mucosal lesions
| Autor: | Mehmet Isler, Selçuk Kaya, Onur Aktürk, Hilmi Demırın, Ulku Saritas, Ibrahim Goren, Metin Ciris, Gülden Başyiğit Kılıç, Altug Senol, Hakan Kuleaşan, Buket Cicioglu Aridogan, Aynur Gül Karahan, Lütfü M Cakmakçi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Gastroenterology Cell Degranulation law.invention chemistry.chemical_compound Probiotic law Internal medicine Malondialdehyde medicine Gastric mucosa Animals Mast Cells Stomach Ulcer Rats Wistar Saline Gastric Lavage Aspirin business.industry Tumor Necrosis Factor-alpha Stomach Probiotics Anti-Inflammatory Agents Non-Steroidal Degranulation Gastric lavage Immunoglobulin A Rats medicine.anatomical_structure chemistry Gastric Mucosa Immunology Interleukin-2 business medicine.drug |
| Zdroj: | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 22(1) |
| ISSN: | 2148-5607 |
| Popis: | We aimed to investigate the role of a probiotic mixture, including 13 different bacteria, in the prevention of aspirin-induced gastric mucosal injury.Forty rats were allocated into 4 groups: normal control, aspirin, probiotic control, and probiotic plus aspirin. Normal control and aspirin groups received 0.2 ml of skim milk by daily gavage for 14 days. Probiotic control and probiotic plus aspirin groups were administered 0.2 ml/day of probiotic mixture (1.3 x 10(10) cfu/ml) suspended in skim milk by daily gavage for 14 days. On day 15, gastric lesions were induced by administration of aspirin (200 mg/kg) in the aspirin and probiotic plus aspirin groups. Normal control and probiotic control groups were given saline.Pretreatment with probiotic mixture reduced aspirin-induced gastric damage scores (4.50 ± 0.43 and 2.60 ± 0.40, p0.01) and exerted tendency of downregulation of proinflammatory cytokines elicited by aspirin (p0.05). We also found that the probiotic mixture increased sIgA production approximately 7.5-fold in the stomach, and significantly reduced the malondialdehyde (MDA) increase in the gastric mucosa elicited by aspirin (p0.001). Additionally, pretreatment with the probiotic mixture alleviated aspirin-induced reduction of mast cell count in the gastric mucosa.Probiotic mixture pretreatment attenuates the aspirin-induced gastric lesions by reducing the lipid peroxidation, enhancing mucosal sIgA production, and stabilizing mucosal mast cell degranulation into the gastric mucosa. |
| Databáze: | OpenAIRE |
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