The Cosmic Silence experiment: on the putative adaptive role of environmental ionizing radiation
| Autor: | Giustina Simone, M.C. Carbone, Eugenio Sorrentino, Orazio Sapora, M. Balata, Mauro Belli, M. A. Tabocchini, L. Ioannucci, S. Nisi, M. Pinto, Fernanda Amicarelli, L. Satta, F. Antonelli, L. Conti Devirgiliis |
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| Rok vydání: | 2008 |
| Předmět: |
DNA damage
environmental radiation tk6 cells Biophysics Linear energy transfer Chinese hamster Antioxidants Ionizing radiation Cell Line adaptive response Radiation Ionizing Background Radiation Humans Lymphocytes Radiometry General Environmental Science Background radiation Cell Proliferation Radiation Micronucleus Tests biology dna damage X-Rays Radiochemistry Dose-Response Relationship Radiation Environmental exposure Environmental Exposure biology.organism_classification Catalase Dose–response relationship Micronucleus test Cancer research DNA Damage |
| Zdroj: | Radiation and environmental biophysics. 48(2) |
| ISSN: | 0301-634X |
| Popis: | Previously we reported that yeast and Chinese hamster V79 cells cultured under reduced levels of background environmental ionizing radiation show enhanced susceptibility to damage caused by acute doses of genotoxic agents. Reduction of environmental radiation dose rate was achieved by setting up an underground laboratory at Laboratori Nazionali del Gran Sasso, central Italy. We now report on the extension of our studies to a human cell line. Human lymphoblastoid TK6 cells were maintained under identical in vitro culture conditions for six continuous months, at different environmental ionizing radiation levels. Compared to “reference” environmental radiation conditions, we found that cells cultured in the underground laboratories were more sensitive to acute exposures to radiation, as measured both at the level of DNA damage and oxidative metabolism. Our results are compatible with the hypothesis that ultra-low dose rate ionizing radiation, i.e. environmental radiation, may act as a conditioning agent in the radiation-induced adaptive response. |
| Databáze: | OpenAIRE |
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