Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction
| Autor: | Patricia Rosell-Negre, Alfonso Barrós-Loscertales, Víctor Costumero, Juan-José Llopis-Llacer, Juan Carlos Bustamante, Paola Fuentes-Claramonte |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male media_common.quotation_subject Medicine (miscellaneous) Cocaine dependence Task (project management) Functional networks Cocaine-Related Disorders 03 medical and health sciences Cognition 0302 clinical medicine Reward motivation Parietal Lobe Neural Pathways medicine Humans Control (linguistics) media_common Pharmacology Motivation left frontoparietal network medicine.diagnostic_test Functional Neuroimaging Addiction Middle Aged medicine.disease Magnetic Resonance Imaging Frontal Lobe 030227 psychiatry Inhibition Psychological Psychiatry and Mental health Case-Control Studies Female Negative correlation cocaine addiction Functional magnetic resonance imaging Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | ADDICTION BIOLOGY r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 1355-6215 |
| Popis: | Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction affected the left frontoparietal network during goal-directed behavior in a stop-signal task (SST) with reward contingencies by correct task performance. Twenty-eight healthy controls (HC) and 30 abstinent cocaine-dependent patients (ACD) performed SST with monetary reward contingencies while undergoing a functional magnetic resonance imaging scan. The results showed that the left frontoparietal network (FPN) displayed an effect of cocaine addiction depending on reward contingencies rather than inhibition accuracy; and, second, we observed a negative correlation between dependence severity and the modulation of the left FPN network by the monetary reward in ACD. These findings highlight the role of the left FPN in the motivational effects of cocaine dependence. |
| Databáze: | OpenAIRE |
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