A gene-driven approach to the identification of ENU mutants in the mouse
| Autor: | Jackie Hunter, Claire Davison, Nicholas J. Parkinson, Steve D.M. Brown, Roger D. Cox, Alison Hugill, Sian Clements, Emma L. Coghill, Peter H. Glenister |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Heterozygote Mutant Mutagenesis (molecular biology technique) Biology medicine.disease_cause Genome chemistry.chemical_compound Mice otorhinolaryngologic diseases Genetics medicine Animals Allele Gene Alleles Mutation Mice Inbred BALB C Mice Inbred C3H Point mutation Mice Mutant Strains chemistry Ethylnitrosourea Female sense organs DNA Mutagens |
| Zdroj: | Nature genetics. 30(3) |
| ISSN: | 1061-4036 |
| Popis: | The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program. |
| Databáze: | OpenAIRE |
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