Disease Severity and Mortality Caused by Dengue in a Dominican Pediatric Population
| Autor: | Alfredo Morales, Alfredo J Mena Lora, Yahaira Soto, Josefina Fernández, Maximo O. Brito, Jesús Feris-Iglesias |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Abdominal pain Pediatrics medicine.medical_specialty Multivariate analysis Adolescent Anemia macromolecular substances Dengue fever Dengue Risk Factors Virology Epidemiology Odds Ratio Humans Medicine Child business.industry Dominican Republic Infant Articles Odds ratio medicine.disease Rash Infectious Diseases Child Preschool Multivariate Analysis Vomiting Female Parasitology medicine.symptom business |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 90:169-172 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.13-0440 |
| Popis: | Millions are infected with dengue yearly. We evaluated the epidemiological and clinical characteristics of pediatric patients infected with dengue in the Dominican Republic. The applicability of World Health Organization (WHO) warning signs for predicting severe dengue and mortality was also studied. This study was a cross-sectional retrospective review of patients with a clinical diagnosis of dengue. Univariate and multivariate analyses were performed to evaluate characteristics associated with severity and mortality. The study included 796 subjects: 288 subjects were classified as dengue, 290 subjects had alarm signs, and 207 subjects were classified as severe dengue. Common findings included thrombocytopenia (96%), abdominal pain (71%), and vomiting (59%). The most important factors associated with severe dengue were rash (P < 0.01), severe thrombocytopenia (P < 0.01), and anemia (P < 0.01). These signs and symptoms were also associated with mortality. This study validates the current WHO warning signs of severity. Rash and severe thrombocytopenia may be early warning signs and need additional study. |
| Databáze: | OpenAIRE |
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