Genetic polymorphisms of glutathione S-transferase Mu 1, glutathione S-transferase theta 1, and glutathione S-transferase P1 in oral squamous cell carcinoma: A case-control study in Iranian population
| Autor: | Mohammad Jafarian, Shima Golmohammadi, Kaveh Yaghmaei, Bahram Yaghmaei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Case-control study
Orthodontics Glutathione Odds ratio Biology Molecular biology Glutathione S-transferase Mu 1 glutathione S-transferase P1 glutathione S-transferase theta 1 oral squamous cell carcinoma polymorphism lcsh:RK1-715 GSTP1 chemistry.chemical_compound stomatognathic diseases Glutathione S-transferase chemistry Glutathione S-Transferase Mu lcsh:Dentistry Genotype biology.protein Oral Surgery Genotyping neoplasms |
| Zdroj: | Journal of Orofacial Sciences, Vol 7, Iss 2, Pp 108-112 (2015) |
| ISSN: | 0975-8844 |
| Popis: | Background: Gene variability related to activation and detoxification of procarcinogens affects the susceptibility to oral squamous cell carcinoma (OSCC). The results of numerous studies investigating the interrelationship between polymorphisms of glutathione S- transferase enzymes are not conclusive and there are little data regarding this topic on Iranian population. Aims and Objectives: This study aimed to investigate the genetic polymorphisms in glutathione S-transferase Mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase P1 (GSTP1) and the association with the risk of OSCC in Iranian population. Materials and Methods: The genetic polymorphisms of GSTM1, GSTT1, and GSTP1 genes were investigated in 35 Iranian patients with the OSCC and 60 age-sex matched controls. GSTP1 genotyping was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism method and GSTM1 and GSTT1 genotyping was amplified with PCR using specific primers. Odds ratios (ORs) and their 95% confidence intervals (CIs) were obtained using SPSS 17 and the risk of OSCC in relation to GSTM1, GSTT1, and GSTP1 polymorphism was defined. Results: The prevalence of GSTM1 and GSTT1 null genotypes in OSCC group were significantly higher than the control group.(OR = 2.6, 95% CI = 1.04-6.5; P = 0.01 for GSTM1) (OR = 11, 95% CI = 9-31; P = 0.001 for GSTT1). The GSTP1 valine polymorphism was not significantly different between the study groups (P = 0.145). Conclusions: GSTM1 and GSTT1 null genotypes may increase the risk for OSCC development in Iranian patients. |
| Databáze: | OpenAIRE |
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