Multidrug-resistant Staphylococcus aureus nasal carriage among HIV-positive outpatients in Guangzhou, China: Prevalence, risk factors, phenotypic and molecular characteristics
Autor: | Wencui Zhang, Linghua Li, Ying Li, Weiping Cai, Zhenjiang Yao, Jialing Lin, Zijun Gong, Suiping He, Jiaping Ye, Xiaohua Ye, Ning Liu |
---|---|
Rok vydání: | 2021 |
Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine Microbiology (medical) China Staphylococcus aureus medicine.medical_specialty 030106 microbiology Population HIV Infections medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Outpatients Prevalence Humans Medicine Pharmacology (medical) 030212 general & internal medicine Risk factor education education.field_of_study business.industry Staphylococcal Infections medicine.disease Anti-Bacterial Agents Multiple drug resistance Cross-Sectional Studies Infectious Diseases Upper respiratory tract infection medicine.anatomical_structure Carriage Nasal Swab Carrier State business Respiratory tract |
Zdroj: | Journal of Infection and Chemotherapy. 27:218-225 |
ISSN: | 1341-321X |
Popis: | Introduction Data on comprehensive characterization of multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) carriage in human immunodeficiency virus (HIV)-positive patients are limited. The objective of the present study is to determine the prevalence, risk factors, phenotypic and molecular characterization of MDR S. aureus isolated from HIV-positive population. Methods A cross-sectional study was conducted to determine the characteristics of MDR S. aureus nasal carriage among HIV-positive outpatients in an HIV clinic from June to August 2017. Nasal swabs and risk factor data of the enrolled HIV-positive outpatients were collected. Phenotypic and molecular characteristics of MDR and non-MDR S. aureus isolates were analyzed. Risk factors for nasal carriage with MDR S. aureus were estimated by logistic regression. The relationship between phenotypic and molecular characteristics of S. aureus isolates was assessed by the correspondence analysis. Results Overall, 1001 HIV-positive outpatients were included. The prevalence of MDR S. aureus nasal carriage was 15.18% (152/1001), and the proportion of multidrug resistance among S. aureus isolates was 60.08% (152/253). Having a history of respiratory tract infection was the risk factor for MDR S. aureus nasal carriage (adjusted odds ratio = 1.90, 95% confidence interval: 1.25–2.89). Multidrug resistance of S. aureus isolates was in good corresponding relationships with clonal complex (CC)5, CC15, CC59 and CC398. Conclusions We found high burden of multidrug resistance among S. aureus isolated from HIV-positive outpatients, particularly in those who had upper respiratory tract infection. Moreover, CC59 and CC398 are highly related to multidrug resistance of S. aureus isolates. |
Databáze: | OpenAIRE |
Externí odkaz: |