Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor
| Autor: | Elvia Coballase-Urrutia, Daniel Ortega-Cuellar, Liliana Carmona-Aparicio, José Pedraza-Chaverri, Elizabeth Moreno-Arriola, Noemí Cárdenas-Rodríguez |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Aging
ved/biology.organism_classification_rank.species Review Article medicine.disease_cause Second Messenger Systems Biochemistry Metabolic Diseases medicine Animals Humans lcsh:QH573-671 Caenorhabditis elegans Model organism Organism chemistry.chemical_classification Reactive oxygen species biology lcsh:Cytology ved/biology Cell Biology General Medicine biology.organism_classification Cell biology Disease Models Animal Oxidative Stress chemistry Second messenger system Phase II Detoxification Signal transduction Reactive Oxygen Species Oxidative stress |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2014 (2014) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Caenorhabditis elegansis a powerful model organism that is invaluable for experimental research because it can be used to recapitulate most human diseases at either the metabolic or genomic levelin vivo. This organism contains many key components related to metabolic and oxidative stress networks that could conceivably allow us to increase and integrate information to understand the causes and mechanisms of complex diseases. Oxidative stress is an etiological factor that influences numerous human diseases, including diabetes.C. elegansdisplays remarkably similar molecular bases and cellular pathways to those of mammals. Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress. However, it is noteworthy that, aside from the detrimental effects of ROS, they have been proposed as second messengers that trigger the mitohormetic response to attenuate the adverse effects of oxidative stress. Herein, we briefly describe the importance ofC. elegansas an experimental model system for studying metabolic disorders related to oxidative stress and the molecular mechanisms that underlie their pathophysiology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text