Regulation of cytoplasmic acetyl-CoA and acetoacetyl-CoA synthetases by dexanethasone phosphate in rat liver and adipose tissue
| Autor: | Monique Wolczunowicz, Simonne Rous |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Adipose tissue macrophages Acetate-CoA Ligase Adipose tissue White adipose tissue Dexamethasone General Biochemistry Genetics and Molecular Biology Acetoacetates chemistry.chemical_compound Internal medicine Acetoacetyl-CoA Coenzyme A Ligases medicine Animals General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification biology Chemistry Acetyl-CoA Fasting General Medicine Enzyme assay Rats Enzyme Endocrinology Adipose Tissue Liver biology.protein medicine.drug |
| Zdroj: | Life Sciences. 20:1347-1351 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(77)90360-5 |
| Popis: | The activity of cytoplasmic acetyl-CoA synthetase and acetoacetyl-CoA synthetase in both liver and adipose tissue was measured in five groups of rats : fed, fasted, fasted and re-fed, fasted, re-fed and injected with dexamethasone during the re-feeding period, fed and injected with dexamethasone. Fasting was found to have a strong inhibitory effect on the activity of the two enzymes in both adipose tissue and liver, which could be abolished by re-feeding. In adipose tissue, dexamethasone prevented this re-establishment of normal enzyme activity but was without effect in the liver. It can therefore be concluded that dexamethasone inhibits the synthesis of acetyl-CoA and acetoacetyl-CoA synthetases in adipose tissue. |
| Databáze: | OpenAIRE |
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