The population genetics of using homing endonuclease genes in vector and pest management
| Autor: | H. C. J. Godfray, Austin Burt, Anne Deredec |
|---|---|
| Přispěvatelé: | BIOlogie et GEstion des Risques en agriculture (BIOGER), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Swiss Federal Institute of Technology, Natural Environment Research Council (NERC), University of Oxford [Oxford], AgroParisTech-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
X Chromosome Gene Transfer Horizontal [SDV]Life Sciences [q-bio] Population Mutant Investigations Disease Vectors Biology Y chromosome 010603 evolutionary biology 01 natural sciences Homing endonuclease Evolution Molecular 03 medical and health sciences Y Chromosome Genetics Homologous chromosome Animals education Gene X chromosome 030304 developmental biology 0303 health sciences education.field_of_study model HEG Gene drive Models Theoretical Endonucleases population genetic engineering Genetics Population [SDE]Environmental Sciences biology.protein Pest Control population control |
| Zdroj: | Genetics Genetics, Genetics Society of America, 2008, 179 (4), pp.2013-2026. ⟨10.1534/genetics.108.089037⟩ |
| ISSN: | 0016-6731 |
| DOI: | 10.1534/genetics.108.089037 |
| Popis: | Homing endonuclease genes (HEGs) encode proteins that in the heterozygous state cause double-strand breaks in the homologous chromosome at the precise position opposite the HEG. If the double-strand break is repaired using the homologous chromosome, the HEG becomes homozygous, and this represents a powerful genetic drive mechanism that might be used as a tool in managing vector or pest populations. HEGs may be used to decrease population fitness to drive down population densities (possibly causing local extinction) or, in disease vectors, to knock out a gene required for pathogen transmission. The relative advantages of HEGs that target viability or fecundity, that are active in one sex or both, and whose target is expressed before or after homing are explored. The conditions under which escape mutants arise are also analyzed. A different strategy is to place HEGs on the Y chromosome that cause one or more breaks on the X chromosome and so disrupt sex ratio. This strategy can cause severe sex-ratio biases with efficiencies that depend on the details of sperm competition and zygote mortality. This strategy is probably less susceptible to escape mutants, especially when multiple X shredders are used. |
| Databáze: | OpenAIRE |
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