Haemolytic complement consumption by Parietaria pollen extracts in relation to peptide-bound flavonoids
| Autor: | B. de la Cuadra López, L. Berrens |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Parietaria
Peptide medicine.disease_cause Hemolysis Cellular and Molecular Neuroscience immune system diseases Flavonoid derivatives Pollen otorhinolaryngologic diseases medicine Humans Molecular Biology Complement Activation Pharmacology chemistry.chemical_classification Flavonoids biology Plant Extracts Cell Biology Plants biology.organism_classification In vitro respiratory tract diseases Complement (complexity) chemistry Biochemistry Immunology Molecular Medicine Pollen extracts |
| Zdroj: | Cellular and molecular life sciences : CMLS. 53(3) |
| ISSN: | 1420-682X |
| Popis: | Inhaled allergens from house dust, mites or animal danders activate human complement in vitro by engaging the C1-component through a non-antibody-dependent mechanism. These earlier findings are extended by showing that the allergenic components in extracts of Parietaria pollen are almost equally potent complement activators as those from house dust or mites. Spectroscopic evidence indicates that haemolytic complement consumption by the Parietaria allergens and their enzymic fragments is most likely related to post-translational side-chains comprising flavonoid derivatives. These adsorbed and/or peptide-bound tannin-like structures may also explain the exceptional stability of the high- and low-molecular mass allergenic components in Parietaria pollen extracts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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