Human neurocysticercosis. IgE in cerebrospinal fluid
| Autor: | Aluízio de Barros Barreto Machado, Carmen Silvia de Melo, Adelaide José Vaz, Paulo Mutuko Nakamura, Marcos Vinícius da Silva |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Immunoenzymatic assay
biology business.industry Cysticercosis Neurocysticercosis neurocysticercosis Immunoglobulin E medicine.disease cerebrospinal fluid Neurosyphilis Cerebrospinal fluid immunoenzymatic assay Neurology Central Nervous System Diseases Immunology medicine biology.protein Humans Bacterial meningitis Neurology (clinical) IgE business Meningitis |
| Zdroj: | Arquivos de Neuro-Psiquiatria v.55 n.1 1997 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| ISSN: | 0004-282X |
| Popis: | The detection of IgE is technically difficult because of its reduced concentrations in serum, and even lower concentrations in cerebrospinal fluid (CSF). In the present investigation we studied 86 CSF samples using an immunoenzymatic method with an anti-IgE-alkaline phosphatase conjugate and a fluorigenic substrate. The samples were from three groups: A) 29 patients with neurocysticercosis (NC), B) 36 patients with different neurologic disorders (neurosyphilis, neurotuberculosis, meningitis, tumors, hemorrhage) and C) 21 discharged individuals who had been hospitalized for bacterial meningitis. The results obtained were: A) 0.05 to 3.00 IU/ml (0.76±0.79), B) 0.00 to 1.50 IU/ml (0.23±0.34) and C) 0.05 to 1.25 IU/ml (0.34±0.34). The present results suggest that IgE appears to play a role in the pathogeny of NC and that efforts should be made to standardize a test for the detection of specific IgE antibodies. |
| Databáze: | OpenAIRE |
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