Associations between peripheral inflammation and resting state functional connectivity in adolescents
| Autor: | Camelia E. Hostinar, Annchen R. Knodt, Johnna R. Swartz, Janina Jiang, Angelica F. Carranza, Laura M. Tully, Michael R. Irwin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Immunology Physiology Posterior parietal cortex Inflammation Amygdala Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neuroimaging Parietal Lobe medicine Humans Child Brain Mapping Resting state fMRI Endocrine and Autonomic Systems business.industry Magnetic Resonance Imaging Peripheral 030104 developmental biology medicine.anatomical_structure Mood Female medicine.symptom business 030217 neurology & neurosurgery Blood sampling |
| Zdroj: | Brain Behav Immun |
| ISSN: | 0889-1591 |
| Popis: | Relatively little is known about associations between peripheral inflammation and neural function in humans. Neuroimaging studies in adults have suggested that elevated peripheral inflammatory markers are associated with altered resting state functional connectivity (rsFC) in several brain networks associated with mood and cognition. Few studies have examined these associations in adolescents, yet scarce data from adolescents point to different networks than adult studies. The current study examined the associations between peripheral inflammation and rsFC in a community sample of adolescents (n = 70; age, 12–15 years; 32 female, 36 male, 2 nonbinary). After blood sampling, an fMRI scan was performed to assess rsFC. Assay for serum inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), was performed. Results indicated that higher TNF-α was associated with altered rsFC between the right amygdala and left striatum and between the right inferior frontal gyrus and left parietal cortex (p < 0.05 whole-brain corrected). Associations with IL-6 and CRP were not significant. In contrast with findings in adults, inflammation may have unique links with the connectivity of the developing adolescent brain. Results have implications for understanding how peripheral inflammation may influence connectivity during adolescence, when neural networks are undergoing major developmental changes. |
| Databáze: | OpenAIRE |
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