Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues
| Autor: | Rovnyak George C, Virginia Shu, Robert C. Millonig, Joseph Schwartz |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Chemical Phenomena Guinea Pigs Anti-Inflammatory Agents Arthritis Pharmacology Mice Inbred strain Edema Drug Discovery medicine Arthus Reaction Animals Hypersensitivity Delayed Primary (chemistry) Arthus reaction Chemistry Rats Inbred Strains medicine.disease Arthritis Experimental Rats Skin reaction Delayed hypersensitivity Rats Inbred Lew Molecular Medicine Pyrazoles medicine.symptom |
| Zdroj: | Journal of medicinal chemistry. 25(12) |
| ISSN: | 0022-2623 |
| Popis: | A series of novel hexahydrothiopyrano[4,3-c]pyrazoles and related analogues were prepared and tested for antiinflammatory activity by using the mouse active Arthus reaction and the delayed hypersensitivity skin reaction in guinea pigs as primary screens. The compounds of most interest, 18 and 28, were further tested in a model of adjuvant-induced arthritis; in this system, both compounds were active when dosed intraperitoneally but failed to produce significant activity when dosed orally at subtoxic doses. |
| Databáze: | OpenAIRE |
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