REM sleep deprivation up-regulates adenosine A1 receptors
| Autor: | Miodrag Radulovacki, George Yanik |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Sleep REM Receptors Cell Surface Endogeny Striatum Tritium Adenosine A1 receptor Internal medicine Cortex (anatomy) medicine Animals Adenosine receptor binding Receptor Molecular Biology Chemistry General Neuroscience Brain Rats Inbred Strains Sleep in non-human animals Rats medicine.anatomical_structure Endocrinology Phenylisopropyladenosine Sleep Deprivation Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 402:362-364 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(87)90046-1 |
| Popis: | Adenosine receptor binding was determined in the brains of rats deprived of rapid eye movement (REM) sleep for 48 and 96 h using [ 3 H] l -phenylisopropyladenosine. Adenosine A 1 receptors ( B max ) were significantly increased in the cortex and corpus striatum, and this increase was sleep-specific. Endogenous adenosine was assayed in microwave-fixed brain tissue and no significant changes were found in REM-deprived rats. |
| Databáze: | OpenAIRE |
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