Oestrogen receptor expression in ductal carcinoma in situ of the breast: relationship to flow cytometric analysis of DNA and expression of the c-erbB-2 oncoprotein
| Autor: | E. C. Roberts, M.H. Galea, R.W. Blamey, David Snead, Jane A Bell, C.W. Elston, Ian O. Ellis, David N. Poller, A. S. Gilmour |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Receptor ErbB-2 Immunocytochemistry Mammary gland Gene Expression Breast Neoplasms Biology S Phase Necrosis Proto-Oncogene Proteins Gene expression Biomarkers Tumor medicine Carcinoma Humans skin and connective tissue diseases Epithelioma Carcinoma in situ Age Factors DNA Neoplasm Middle Aged Ductal carcinoma Aneuploidy Flow Cytometry medicine.disease Diploidy Immunohistochemistry Carcinoma Intraductal Noninfiltrating medicine.anatomical_structure Receptors Estrogen Oncology Female Carcinoma in Situ Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1993.305 |
| Popis: | The expression of oestrogen receptor protein (ER) was examined in 151 cases of symptomatic or screening detected pure ductal carcinoma in situ (DCIS) of the breast by immunocytochemical assay (ERICA), in formalin-fixed paraffin-embedded tissue, with the monoclonal antibody H 222 (Abbott). Forty-eight tumours (31.8%) of cases were ER positive. Twenty-seven (17.9%) of cases showed high level ER expression and 21 (13.9%) of cases showed low level ER immunoreactivity. Significant associations of positive tumour ER immunoreactivity and non-comedo architecture chi 2 = 6.76; (d.f. = 1): P < 0.001, small cell size chi 2 = 4.49; (d.f. = 1): P = 0.034, higher S-phase fraction chi 2 = 4.71; (d.f. = 1): P = 0.03 and lack of c-erbB-2 protein overexpression chi 2 = 7.96; (d.f. = 1): P < 0.01 were identified. No significant associations of ER expression and patient age, histological grade of necrosis in DCIS, or DNA ploidy were found. ER expression is detectable in less than one third of symptomatic and screening detected cases of DCIS, implying that endocrine therapy of DCIS may be a more appropriate form of management for morphological subtypes of DCIS which show higher rates of oestrogen receptor expression, particularly those of non-comedo and small cell type. Images Figure 1 |
| Databáze: | OpenAIRE |
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