Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS) : a descriptive study
| Autor: | Jukka P. Mecklin, Kirsi Pylvänäinen, K. Sorvettula, Heini Huhtala, Synnöve Staff, Toni T. Seppälä, Mari H. Kalamo, Johanna Mäenpää |
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| Přispěvatelé: | HUS Abdominal Center, Clinicum, II kirurgian klinikka, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
SURGERY medicine.medical_treatment Pain Procedural 0302 clinical medicine Surveys and Questionnaires Epidemiology Prophylactic surgery Finland Genetics (clinical) Aged 80 and over RISK Surveillance medicine.diagnostic_test Obstetrics Middle Aged 16. Peace & justice Prophylactic Surgery Lynch syndrome 3. Good health DNA-Binding Proteins prophylactic surgery MutS Homolog 2 Protein Oncology Patient Satisfaction 030220 oncology & carcinogenesis surveillance Female Original Article 030211 gastroenterology & hepatology MutL Protein Homolog 1 Adult Heterozygote medicine.medical_specialty Decision Making 3122 Cancers HNPCC Hysterectomy ehkäisevä lääketiede 03 medical and health sciences Syöpätaudit - Cancers Genetics medicine Carcinoma Humans Genetic Testing Lynchin oireyhtymä Aged Retrospective Studies Cancer prevention business.industry Endometrial cancer ENDOMETRIAL CANCER medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Endometrial Neoplasms business Endometrial biopsy |
| Zdroj: | Familial Cancer |
| Popis: | To prevent endometrial carcinoma in Lynch syndrome (LS), regular gynecological surveillance visits and prophylactic surgery are recommended. Previous data have shown that prophylactic hysterectomy is an effective means of cancer prevention, while the advantages and disadvantages of surveillance are somewhat unclear. We aimed to evaluate female LS carriers’ attitudes towards regular gynecological surveillance and factors influencing their decision-making on prophylactic surgery that have not been well documented. Pain experienced during endometrial biopsies was also evaluated. Postal questionnaires were sent to LS carriers undergoing regular gynecological surveillance. Questionnaires were sent to 112 women with LS, of whom 76 responded (68%). Forty-two (55%) had undergone prophylactic hysterectomy by the time of the study. The majority of responders (64/76; 84.2%) considered surveillance appointments beneficial. Pain level during endometrial biopsy was not associated with the decision to undergo prophylactic surgery. The level of satisfaction the women had with the information and advice provided during surveillance was significantly associated with the history of prophylactic hysterectomy (satisfaction rate of 73.2% versus 31.8% of nonoperated women, p = 0.003). The women who had undergone prophylactic surgery were older than the nonoperated women both at mutation testing (median of 42.3 years versus 31.6 years, p p |
| Databáze: | OpenAIRE |
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