Cross-Protection to New Drifted Influenza A(H3) Viruses and Prevalence of Protective Antibodies to Seasonal Influenza, During 2014 in Portugal
| Autor: | Paula Cristóvão, Manuel Maurílio, Ana Coelho, Aida Fernandes, Mário Cunha, Pedro Pechirra, Susana Silva, Ana Paula Rodrigues, Filipa Dantas, Fernando Rodrigues, Patrícia Conde, Ana Rita Couto, Jácome Bruges-Armas, Rita Cabral Veloso, Filomena Caldeira, Raquel Sanches, Rita Mouro Pinto, Baltazar Nunes, João Pereira-Vaz, Marta C. Soares, Rita Côrte-Real, Regina Viseu, Maria do Rosário Costa, Luís Martins, Luís Milho, Ludovina Freitas, Lurdes Correia, Sofia Almeida, Maria João Peres, Ana Carina Maia, Graça Andrade, Raquel Guiomar, João Tiago Guimarães, Paula Branquinho, Luisa Mota-Vieira, Paula Caseiro, Joana Sobrinho Simões |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Infecções Respiratórias
0301 basic medicine Male Veterinary medicine Cross Protection Seroprevalence medicine.disease_cause Antibodies Viral Serology 0302 clinical medicine Seroepidemiologic Studies Influenza A virus 030212 general & internal medicine Child Aged 80 and over Incidence (epidemiology) Incidence Antibody titer Middle Aged Vaccination Infectious Diseases Child Preschool Molecular Medicine Female Cross-protection Adult Adolescent 030106 microbiology Virus 03 medical and health sciences Young Adult CHLC PAT CLIN Influenza Human medicine Humans Aged Hemagglutination assay General Veterinary General Immunology and Microbiology Portugal business.industry Public Health Environmental and Occupational Health Infant Newborn Infant Hemagglutination Inhibition Tests Estados de Saúde e de Doença Influenza Cross-Sectional Studies business |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| Popis: | Em colaboração com a Rede Portuguesa de Laboratóros para o Diagnóstico da Gripe Introduction: Immune profile for influenza viruses is highly changeable over time. Serological studies can assess the prevalence of influenza, estimate the risk of infection, highlight asymptomatic infection rate and can also provide data on vaccine coverage. The aims of the study were to evaluate pre-existing cross-protection against influenza A(H3) drift viruses and to assess influenza immunity in the Portuguese population. Materials and methods: We developed a cross-sectional study based on a convenience sample of 626 sera collected during June 2014, covering all age groups, both gender and all administrative health regions of Portugal. Sera antibody titers for seasonal and new A(H3) drift influenza virus were evaluated by hemagglutination inhibition assay (HI). Seroprevalence to each seasonal influenza vaccine strain virus and to the new A(H3) drift circulating strain was estimated by age group, gender and region and compared with seasonal influenza-like illness (ILI) incidence rates before and after the study period. Results: Our findings suggest that seroprevalences of influenza A(H3) (39.9%; 95% CI: 36.2–43.8) and A(H1)pdm09 (29.7%; 95% CI: 26.3–33.4) antibodies were higher than for influenza B, in line with high ILI incidence rates for A(H3) followed by A(H1)pdm09, during 2013/2014 season. Low pre-existing crossprotection against new A(H3) drift viruses were observed in A(H3) seropositive individuals (46%). Both against influenza A(H1)pdm09 and A(H3) seroprotection was highest in younger than 14-years old. Protective antibodies against influenza B were highest in those older than 65 years old, especially for B/Yamagata lineage, 33.3% (95% CI: 25.7–41.9). Women showed a high seroprevalence to influenza, although without statistical significance, when compared to men. A significant decreasing trend in seroprotection from north to south regions of Portugal mainland was observed. Conclusions: Our results emphasize that low seroprotection increases the risk of influenza infection in the following winter season. Seroepidemiological studies can inform policy makers on the need for vaccination and additional preventive measures. This work was supported by the National Institute of Health Doutor Ricardo Jorge, IP Lisbon, Portugal. info:eu-repo/semantics/acceptedVersion |
| Databáze: | OpenAIRE |
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