Peak Width of Skeletonized Mean Diffusivity as Neuroimaging Biomarker in Cerebral Amyloid Angiopathy
| Autor: | Li Xiong, Steven M. Greenberg, Andreas Charidimou, Dorothee Schoemaker, N. Raposo, Panagiotis Fotiadis, Mahmut Edip Gurol, M. Duering, Mark R Etherton, Marco Pasi, K. Schwab, M.C. Zanon Zotin, Gregoire Boulouis, Markus D. Schirmer, Anand Viswanathan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
psychology [Cerebral Amyloid Angiopathy] diagnostic imaging [Cognitive Dysfunction] methods [Diffusion Tensor Imaging] 030218 nuclear medicine & medical imaging 0302 clinical medicine Cognition methods [Image Processing Computer-Assisted] Image Processing Computer-Assisted Aged 80 and over education.field_of_study diagnostic imaging [Cerebral Amyloid Angiopathy] medicine.anatomical_structure Diffusion Tensor Imaging Cardiology Biomarker (medicine) Female Cerebral amyloid angiopathy diagnostic imaging [Cerebral Small Vessel Diseases] psychology [Cognitive Dysfunction] medicine.medical_specialty Amyloid Population Neuroimaging White matter 03 medical and health sciences Internal medicine mental disorders medicine Reaction Time Humans Radiology Nuclear Medicine and imaging Cognitive Dysfunction ddc:610 education Aged business.industry Adult Brain Mean age medicine.disease Cerebral Amyloid Angiopathy Diffusion Magnetic Resonance Imaging Cerebral Small Vessel Diseases Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers Psychomotor Performance |
| Zdroj: | American journal of neuroradiology 42(5), 875-881 (2021). doi:10.3174/ajnr.A7042 AJNR Am J Neuroradiol |
| DOI: | 10.3174/ajnr.A7042 |
| Popis: | BACKGROUND AND PURPOSE: Whole-brain network connectivity has been shown to be a useful biomarker of cerebral amyloid angiopathy and related cognitive impairment. We evaluated an automated DTI-based method, peak width of skeletonized mean diffusivity, in cerebral amyloid angiopathy, together with its association with conventional MRI markers and cognitive functions. MATERIALS AND METHODS: We included 24 subjects (mean age, 74.7 [SD, 6.0] years) with probable cerebral amyloid angiopathy and mild cognitive impairment and 62 patients with MCI not attributable to cerebral amyloid angiopathy (non-cerebral amyloid angiopathy–mild cognitive impairment). We compared peak width of skeletonized mean diffusivity between subjects with cerebral amyloid angiopathy–mild cognitive impairment and non-cerebral amyloid angiopathy–mild cognitive impairment and explored its associations with cognitive functions and conventional markers of cerebral small-vessel disease, using linear regression models. RESULTS: Subjects with Cerebral amyloid angiopathy–mild cognitive impairment showed increased peak width of skeletonized mean diffusivity in comparison to those with non-cerebral amyloid angiopathy–mild cognitive impairment (P < .001). Peak width of skeletonized mean diffusivity values were correlated with the volume of white matter hyperintensities in both groups. Higher peak width of skeletonized mean diffusivity was associated with worse performance in processing speed among patients with cerebral amyloid angiopathy, after adjusting for other MRI markers of cerebral small vessel disease. The peak width of skeletonized mean diffusivity did not correlate with cognitive functions among those with non-cerebral amyloid angiopathy–mild cognitive impairment. CONCLUSIONS: Peak width of skeletonized mean diffusivity is altered in cerebral amyloid angiopathy and is associated with performance in processing speed. This DTI-based method may reflect the degree of white matter structural disruption in cerebral amyloid angiopathy and could be a useful biomarker for cognition in this population. |
| Databáze: | OpenAIRE |
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