Promising Potential of Lonchocarpus utilis against South American Myasis
| Autor: | José Blanco-Salas, Juan Carlos Alías-Gallego, Trinidad Ruiz-Téllez, Carmen X. Luzuriaga-Quichimbo, Carlos E. Cerón-Martínez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Conventional medicine
Primary health care Plant Science 01 natural sciences drug discovery Synthetic drugs 03 medical and health sciences Ecology Evolution Behavior and Systematics 030304 developmental biology Lonchocarpus utilis 0303 health sciences Ecology biology Traditional medicine bioinformatic Botany food and beverages barbasco biology.organism_classification rotenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry in silico South american QK1-989 Neglected tropical diseases |
| Zdroj: | Plants Volume 9 Issue 1 Plants, Vol 9, Iss 1, p 33 (2019) |
| ISSN: | 2223-7747 |
| DOI: | 10.3390/plants9010033 |
| Popis: | Traditional medicine is especially important in the treatment of neglected tropical diseases because it is the way the majority of populations of affected countries manage primary healthcare. We present a case study that can serve as an example that can be replicated by others in the same situation. It is about the validation of a local remedy for myasis in Amazonian Ecuador, which is contrasted by bibliographic chemical reviews and in silico activity tests. We look for scientific arguments to demonstrate the reason for using extracts of Lonchocarpus utilis against south American myasis (tupe). We provide a summary of the isoflavonoids, prenylated flavonoids, chalcones, and stilbenes that justify the action. We make modeling predictions on the affinity of eight chemical components and enzyme targets using Swiss Target Prediction software. We conclude that the effects of this extract can be reasonably attributed to an effect of the parasite that causes the disease, similar to the one produced by synthetic drugs used by conventional medicine (e.g., Ivermectine). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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