Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

Autor: Ana Beatriz Franco-Sena, Claudio J. Struchiner, Gilberto Kac, Fernanda Rebelo
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Physiology
Peptide Hormones
Maternal Health
lcsh:Medicine
Blood Pressure
Pathology and Laboratory Medicine
Biochemistry
Vascular Medicine
Labor and Delivery
0302 clinical medicine
Pregnancy
Immune Physiology
Blood plasma
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Prospective cohort study
lcsh:Science
Breast Milk
Immune Response
Innate Immune System
Multidisciplinary
Obstetrics
Postpartum Period
Obstetrics and Gynecology
Hematology
Body Fluids
Blood
Milk
Obstetric Procedures
Cohort
Cytokines
Female
Adiponectin
Anatomy
Live birth
Live Birth
Research Article
Adult
medicine.medical_specialty
Immunology
030209 endocrinology & metabolism
Surgical and Invasive Medical Procedures
Blood Plasma
03 medical and health sciences
Insulin resistance
Signs and Symptoms
Adipokines
Diagnostic Medicine
medicine
Humans
Inflammation
business.industry
Cesarean Section
lcsh:R
Biology and Life Sciences
Molecular Development
medicine.disease
Hormones
Immune System
Birth
Women's Health
lcsh:Q
business
Postpartum period
Developmental Biology
Zdroj: PLoS ONE, Vol 11, Iss 7, p e0158886 (2016)
PLoS ONE
ISSN: 1932-6203
Popis: Introduction Maternal plasma adiponectin is inversely related to insulin resistance, atherosclerosis and child health. However, little is known about its concentrations in the perinatal period, especially according to mode of delivery. Our aim is to evaluate the association between mode of delivery and changes in maternal plasma adiponectin from 3rd trimester of pregnancy to 30–45 days postpartum. Methods A cohort was recruited in Rio de Janeiro, Brazil, with four waves of follow-up: 5-13th, 22-26th, 30-36th gestational weeks and 30–45 days postpartum. Eligible subjects should be between 20–40 years of age, be free of chronic and infectious diseases and presenting with a singleton pregnancy. The mode of delivery was classified as vaginal (VD) or cesarean (CS). Plasma adiponectin concentration (μg/mL) was measured using commercial ELISA kits. Statistical analyses included the Wilcoxon rank-sum test and the multiple linear mixed effects model. Results A total of 159 participated in the study. Median adiponectin concentrations were higher for the VD group (n = 99; 8.25, IQR: 5.85–11.90) than for the CS group (n = 60; 7.34, IQR: 4.36–9.76; p = 0.040) in the postpartum samples but were not different between the two groups in the 3rd trimester. Women who underwent CS had a lower rate of increase in adiponectin concentration from the 3rd trimester to 30–45 days postpartum compared to those who underwent VD (β = -.15, 95% CI: -.28-.02, p = 0.030). Conclusion The CS procedure was associated with lower maternal circulating concentrations of adiponectin at 30–45 days postpartum, compared to the VD.
Databáze: OpenAIRE
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