Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight
Autor: | Lars Westberg, Jessica Bah, Elias Eriksson, Göran Holm, Fariba Baghaei, Jonas Melke, Susanne Henningsson, Roland Rosmond |
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Rok vydání: | 2010 |
Předmět: |
Adult
Male medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Single-nucleotide polymorphism Overweight Biology Body Mass Index Endocrinology Internal medicine Receptor Serotonin 5-HT2C medicine Humans Allele Promoter Regions Genetic Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic Body Weight Haplotype Female medicine.symptom Underweight Body mass index Weight gain |
Zdroj: | Metabolism. 59:1156-1163 |
ISSN: | 0026-0495 |
DOI: | 10.1016/j.metabol.2009.11.007 |
Popis: | Receptors of the 5-HT2C subtype are of importance for the influence of serotonin on food intake, and 2 single nucleotide polymorphisms in this gene (HTR2C)--Cys23Ser (rs6318) and -759CT (rs3813929)--have been reported to be associated with weight and/or antipsychotic-induced weight gain. The present study aimed to replicate these associations; in addition, the 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) was assessed. The polymorphisms were genotyped in subjects recruited from the normal population (n = 510), and possible associations between genotype and body mass index (BMI) were assessed. The Ser23 allele was more common in underweight subjects (BMI20) than in normal- and overweight (BMIor =20) subjects (P = .006). The T allele of the -759C/T polymorphism was less common in the overweight group (BMIor =25) (P = .007). Homozygosity for the short allele of 5-HTTLPR was more frequent in underweight subjects (P = .015). Our results are in agreement with previous studies, suggesting polymorphisms in HTR2C to be associated with body weight, particularly in women; and they also suggest that 5-HTTLPR may influence this phenotype. Further studies on the importance of the investigated genes for eating disorders and drug-induced weight gain are warranted. |
Databáze: | OpenAIRE |
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