Mother-Newborn Pairs in Malawi Have Similar Antibody Repertoires to Diverse Malaria Antigens
| Autor: | Christopher V. Plowe, Mark A. Travassos, Titus H. Divala, Jason A. Bailey, Algis Jasinskas, Jenny A. Walldorf, Jozelyn Pablo, Patricia Mawindo, Philip L. Felgner, Amed Ouattara, Matthew Adams, Sarah Boudova, Rie Nakajima, Miriam K. Laufer, Randy G. Mungwira |
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| Přispěvatelé: | Edwards, Kathryn M |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Malawi and promotion of well-being Placenta Clinical Biochemistry Antibodies Protozoan Reproductive health and childbirth placental malaria Maternally-Acquired 0302 clinical medicine Pregnancy vaccine Immunology and Allergy 2.1 Biological and endogenous factors 030212 general & internal medicine Malaria Falciparum Aetiology Child Pediatric biology Malaria vaccine vaccines Fetal Blood Antigenic Variation medicine.anatomical_structure Infectious Diseases 3.4 Vaccines Parasitic Protozoan Female Antibody Infection Biotechnology Microbiology (medical) Falciparum Adult Adolescent Plasmodium falciparum Immunology Protein Array Analysis malaria Mothers Antigens Protozoan Microbiology Antibodies Vaccine Related 03 medical and health sciences Young Adult Rare Diseases Antigen Antibody Repertoire Immunity Clinical Research parasitic diseases Malaria Vaccines antibody repertoire medicine Humans Antigens antigenic diversity business.industry Prevention Infant Newborn Infant Perinatal Period - Conditions Originating in Perinatal Period biology.organism_classification medicine.disease Newborn Prevention of disease and conditions Virology Malaria Pregnancy Complications Vector-Borne Diseases 030104 developmental biology Good Health and Well Being protein microarray Pregnancy Complications Parasitic Immunoglobulin G biology.protein Clinical Immunology Immunization business Immunity Maternally-Acquired |
| Zdroj: | Clinical and vaccine immunology : CVI, vol 24, iss 10 |
| Popis: | Maternal antibodies may play a role in protecting newborns against malaria disease. Plasmodium falciparum parasite surface antigens are diverse, and protection from infection requires allele-specific immunity. Although malaria-specific antibodies have been shown to cross the placenta, the extent to which antibodies that respond to the full repertoire of diverse antigens are transferred from the mother to the infant has not been explored. Understanding the breadth of maternal antibody responses and to what extent these antibodies are transferred to the child can inform vaccine design and evaluation. We probed plasma from cord blood and serum from mothers at delivery using a customized protein microarray that included variants of malaria vaccine target antigens to assess the intensity and breadth of seroreactivity to three malaria vaccine candidate antigens in mother-newborn pairs in Malawi. Among the 33 paired specimens that were assessed, mothers and newborns had similar intensity and repertoire of seroreactivity. Maternal antibody levels against vaccine candidate antigens were the strongest predictors of infant antibody levels. Placental malaria did not significantly impair transplacental antibody transfer. However, mothers with placental malaria had significantly higher antibody levels against these blood-stage antigens than mothers without placental malaria. The repertoire and levels of infant antibodies against a wide range of malaria vaccine candidate antigen variants closely mirror maternal levels in breadth and magnitude regardless of evidence of placental malaria. Vaccinating mothers with an effective malaria vaccine during pregnancy may induce high and potentially protective antibody repertoires in newborns. |
| Databáze: | OpenAIRE |
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