216. Glutamate Dehydrogenase-Deficient Mice: A Novel Mouse Model of Schizophrenia-Like Phenotypes
| Autor: | Pierre Maechler, Stephen Rayport, Hanoch Kaphzan, Sharon S Lander, Reut Donner, Susana Mingote, Scott A. Small, Frank A. Provenzano, Nicole M. Lewandowski, Darpan Chakraborti, Inna Gaisler-Salomon |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Schizophrenia Bulletin. 43:S109-S110 |
| ISSN: | 1745-1701 0586-7614 |
| Popis: | Background: Glutamatergic abnormalities are commonly observed in schizophrenia (SZ), but all current medications for SZ symptoms target monoaminergic neurotransmitter systems, and are inefficient in treating all symptom clusters. Animal models that capture glutamatergic abnormalities in SZ and mimic its behavioral and neurochemical attributes are critical for better understanding of the neurobiology of the disorder and for the development of new pharmacological treatments. Recent findings indicate that expression of glutamate dehydrogenase (Glud1) mRNA is reduced in the hippocampus of patients with SZ, particularly in the CA1 subregion. Glud1 encodes the GDH protein, a mitochondrial enzyme that converts glutamate to alpha-ketoglutarate. Aim: To assess whether a CNS-specific deletion of Glud1 in nestin-cre::GLUD1 lox/+ (CNS-GLUD1+/−) mice or nestin-cre::GLUD1 lox/lox (CNS-GLUD1−/−) mice leads to abnormal glutamate levels, abnormal hippocampal physiology or gene expression, or behavioral alterations relevant to SZ psychopathology. |
| Databáze: | OpenAIRE |
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