Effects of intensity-modulated radiotherapy and chemoradiotherapy on attention in patients with nasopharyngeal cancer
| Autor: | Ling Qin, Ling Li, Zheng-You Liang, Su-Ping Tao, Xiao-Dong Zhu, Yan-Lin Mo, Qing Wei, Jia-Li Deng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment media_common.quotation_subject chemoradiotherapy Auditory Continuous Performance Test 03 medical and health sciences integrated visual and auditory continuous performance test 0302 clinical medicine Internal medicine medicine Cognitive decline Depression (differential diagnoses) media_common business.industry nasopharyngeal carcinoma Cancer intensity-modulated radiotherapy medicine.disease attention Surgery Radiation therapy stomatognathic diseases Nasopharyngeal carcinoma 030220 oncology & carcinogenesis business 030217 neurology & neurosurgery Chemoradiotherapy Research Paper Vigilance (psychology) |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Qing Wei 1, 2 , Ling Li 1 , Xiao-Dong Zhu 1 , Ling Qin 3 , Yan-Lin Mo 4 , Zheng-You Liang 5 , Jia-Li Deng 1 and Su-Ping Tao 1 1 Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Nanning 530021, China 2 Department of Radiation Oncology, Yantai Yuhuangding Hospital, Yantai 264000, China 3 Center for Sleep and Cognition, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China 4 National Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China 5 Department of Computer, Guangxi University, Nanning 530021, China Correspondence to: Ling Li, email: liling2015123@163.com Keywords: nasopharyngeal carcinoma, intensity-modulated radiotherapy, chemoradiotherapy, attention, integrated visual and auditory continuous performance test Received: January 17, 2017 Accepted: June 28, 2017 Published: July 25, 2017 ABSTRACT This study evaluated the short-term effects of intensity-modulated radiotherapy (IMRT) and cisplatin concurrent chemo-radiotherapy (CCRT) on attention in patients with nasopharyngeal cancer (NPC). Timely detection and early prevention of cognitive decline are important in cancer patients, because long-term cognitive effects may be permanent and irreversible. Thirty-eight NPC patients treated with IMRT (17/38) or CCRT (21/38) and 38 healthy controls were recruited for the study. Neuropsychological tests were administered to each patient before treatment initiation and within a week after treatment completion. Changes in attention performance over time were evaluated using difference values (D-values). Decreased attention was already observable in patients with NPC prior to treatment. Baseline quotient scores for auditory attention, auditory and visual vigilance, and auditory speed were lower in patients treated with CCRT than in healthy controls (P=0.037, P=0.001, P=0.007, P=0.032, respectively). Auditory stamina D-values were higher in patients treated with IMRT alone ( P =0.042), while full-scale response control quotient D-values were lower in patients treated with CCRT ( P =0.030) than in healthy controls. Gender, depression, education, and sleep quality were each related to decreased attention and response control. Our results showed that IMRT had no negative acute effects on attention in NPC patients, while CCRT decreased response control. |
| Databáze: | OpenAIRE |
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