Pharmacokinetics, Effect on Clotting Tests and Assessment of the Immunogenic Potential of Hirudin after a Single Subcutaneous or Intravenous Bolus Administration in Man
| Autor: | Hans Fritz, J. Bichler, B. Fichtl, Matthias Siebeck |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Metabolic Clearance Rate
medicine.drug_class Injections Subcutaneous Thrombin Time Radioimmunoassay Hirudin Urine Pharmacology Thrombin time Intravenous bolus Histamine Release Pharmacokinetics Physiology (medical) medicine Humans Thromboplastin Blood Coagulation medicine.diagnostic_test biology business.industry Anticoagulant Thrombin Body Fluid Compartments Hematology Hirudins Immunoglobulin E Immunoglobulin G Anesthesia Injections Intravenous biology.protein Biological Assay Partial Thromboplastin Time Antibody business Half-Life medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1424-8840 1424-8832 |
| Popis: | The pharmacokinetics and the anticoagulant effects of hirudin were investigated in 12 healthy volunteers after single subcutaneous or intravenous bolus administrations. Hirudin concentrations in citrated plasma and urine were determined with a radioimmunobioassay, which detects the inhibitor by its thrombin-binding capactiy. Plasma profiles could be adequately described by the equation for an open two-compartment model (intravenous route) and by the Bateman equation (subcutaneous route), respectively. Within 24 h half of the administered hirudin dose was recovered in the urine in biologically active form. The prolongation of clotting times (activated partial thromboplastin and thrombin time) was dependent on the hirudin plasma concentration. All test subjects tolerated the hirudin injection without visible or measurable side effects. No hirudin-specific antibodies were found after single parenteral administrations. |
| Databáze: | OpenAIRE |
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