In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)
| Autor: | Christopher T. Elliott, David J. Grieve, Brian D. Green, EP Rafferty, A.R.G. Wylie, Olivier P. Chevallier |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
endocrine system Short Communication Glutamine Casein Pharmaceutical Science Alpha (ethology) Biology Olive leaf extract In vivo Internal medicine medicine Secretion digestive oral and skin physiology Diabetes Chlorogenic acid Glucagon-like peptide-1 Hormone In vitro Endocrinology Glucose hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scientia Pharmaceutica |
| ISSN: | 2218-0532 |
| Popis: | Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P |
| Databáze: | OpenAIRE |
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