The neurochemical consequences of methamphetamine self-administration in male and female rats
| Autor: | Andrew Johansen, Lisa M. McFadden |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Substance-Related Disorders media_common.quotation_subject Self Administration Toxicology Hippocampus Article Methamphetamine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neurochemical medicine Animals Pharmacology (medical) media_common Dopamine transporter Pharmacology Brain-derived neurotrophic factor Dopamine Plasma Membrane Transport Proteins biology Addiction Brain-Derived Neurotrophic Factor Meth Corpus Striatum 030227 psychiatry Rats Psychiatry and Mental health chemistry biology.protein Female Self-administration Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug and alcohol dependence. 178 |
| ISSN: | 1879-0046 |
| Popis: | Methamphetamine (METH) is an addictive substance that is used in both males and females. Few preclinical studies have focused on understanding sex-differences in the neurochemical consequences of contingent METH. The purpose of the current study was to investigate potential sex-differences in the neurochemical consequences of METH self-administration.Male and female adult rats were given extended access to METH or saline self-administration for 7d. Following self-administration, hippocampal brain-derived neurotrophic factor (BDNF) and striatal dopamine transporter (DAT) were assessed via western blotting.Male and female rats had similar METH intake. METH self-administration reduced striatal DAT in both sexes, but only males that self-administered METH had elevated hippocampal BDNF levels.Sex-differences exist in the neurochemical consequences of METH self-administration. These differences may lead to sex-specific vulnerability to the toxic effects of METH. |
| Databáze: | OpenAIRE |
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