A Simple Mechanism Based on Amino Acid Substitutions is not a Critical Determinant of High Mortality of Japanese Encephalitis Virus Infection in Mice
| Autor: | Mark Anthony Luz, Leo Uchida, Daisuke Hayasaka, Muhareva Raekiansyah, Kouichi Morita, Yuki Takamatsu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:QR1-502 Virulence Genome Viral Biology medicine.disease_cause Virus lcsh:Microbiology Article law.invention 03 medical and health sciences Mice law Virology Complementary DNA medicine Animals pathogenicity Mortality recombinant Encephalitis Japanese mouse chemistry.chemical_classification Encephalitis Virus Japanese Recombination Genetic Mutation High mortality Japanese encephalitis medicine.disease Amino acid Japanese encephalitis virus 030104 developmental biology Infectious Diseases chemistry Recombinant DNA amino acid substitution |
| Zdroj: | Viruses Viruses; Volume 10; Issue 2; Pages: 62 Viruses, Vol 10, Iss 2, p 62 (2018) |
| Popis: | For the development of effective treatment strategies for Japanese encephalitis (JE), it is important to identify the viral factors causing severe disease during JE virus (JEV) infection. In this study, we assessed whether amino acid substitutions are critical factors for higher mortality of JaTH160 compared with JaOArS982 in mice using the technique of infectious cDNA clones. We raised the possibility that two amino acids of C124 and NS3482 of JaTH160 may contribute to increased mortality in mice. However, simultaneous substitutions of these amino acids did not significantly increase the virulence of JaOArS982, suggesting that high mortality due to JaTH160 viral infection cannot be simply attributed to the specific amino acids. Multiple and complex, but not simple, mechanisms may induce the high mortality of JaTH160 infection in mice. Viruses, 10(2), 62; 2018 |
| Databáze: | OpenAIRE |
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