Complications after surgery for benign prostatic enlargement: a population-based cohort study in Ontario, Canada
| Autor: | Christopher J.D. Wallis, Joseph LaBossiere, Erind Dvorani, Girish Kulkarni, Lesley K. Carr, Ronald T. Kodama, Robert K. Nam, Refik Saskin, Rano Matta, Sender Herschorn, Sidney B. Radomski, Amanda Hird |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Databases Factual Urology Population 030232 urology & nephrology adrenergic alpha-antagonists Prostatic Hyperplasia 5-alpha reductase inhibitors 03 medical and health sciences 0302 clinical medicine Postoperative Complications Fibrinolytic Agents Antithrombotic postoperative haemorrhage Preoperative Care Medicine Humans education Original Research Aged Retrospective Studies Aged 80 and over Ontario education.field_of_study benign prostatic hyperplasia urinary retention business.industry Urinary retention Postoperative complication General Medicine medicine.disease Prostatic enlargement Comorbidity Surgery 030220 oncology & carcinogenesis Multivariate Analysis Linear Models medicine.symptom Complication business Cohort study |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectivesTo examine the complication rates after benign prostatic enlargement (BPE) surgery and the effects of age, comorbidity and preoperative medical therapy.DesignA retrospective, population-based cohort study using linked administrative data.SettingOntario, Canada.Participants52 162 men≥66 years undergoing first BPE surgery between 1 January 2003 to 31 December 2014.InterventionMedical therapy preoperatively and surgery for BPE.Primary and secondary outcome measuresThe primary outcome was overall 30-day postoperative complication rates. Secondary outcomes included BPE-specific event rates (bleeding, infection, obstruction, trauma) and non-BPE specific event rates (cardiovascular, pulmonary, thromboembolic and renal). Multivariable analysis examined the association between preoperative medical therapy and postoperative complication rates.ResultsThe 30-day overall complication rate after BPE surgery was 2828 events/10 000 procedures and increased annually over the study period. Receipt of preoperative α-blocker monotherapy (relative rate (RR) 1.05; 95% CI 1.00 to 1.09; p=0.033) and antithrombotic medications (RR 1.27; 95% CI 1.22 to 1.31; pConclusionsThirty-day complication rates after BPE surgery have increased annually between 2003 and 2014. Preoperative medical therapy with alpha blockers or antithrombotics was independently associated with higher rates of complications. Over this time, the duration of conservative therapy also increased. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|