Catheter-assisted 18F-FDG-PET/CT imaging of primary bladder cancer
| Autor: | Annemarie Fioole-Bruining, N.M. Bruin, Erik Vegt, Bas W.G. van Rhijn, Willem de Blok, Simon Horenblas, Laura S. Mertens, Wouter V. Vogel |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology medicine.medical_specialty Catheters medicine.medical_treatment Foley catheter urologic and male genital diseases Multimodal Imaging Fluorodeoxyglucose F18 Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Saline Aged Bladder cancer medicine.diagnostic_test business.industry General Medicine Cystoscopy Middle Aged medicine.disease Confidence interval Catheter Urinary Bladder Neoplasms Positron-Emission Tomography Female Histopathology Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | Nuclear Medicine Communications. 33:1195-1201 |
| ISSN: | 0143-3636 |
| Popis: | OBJECTIVE The purpose of this study was to prospectively investigate the value of a standardized 18F-fluorodeoxyglucose (18F-FDG)-PET/computed tomography (CT) protocol for imaging of primary bladder cancer, using standardized bladder flushing and filling. METHODS We included 19 patients with cT1-4 bladder cancer. A Foley catheter was inserted before 18F-FDG injection. PET/CT imaging was performed according to four bladder protocols: (1) bladder empty; (2) bladder empty after flushing; (3) bladder filled with 50 ml saline; and (4) bladder filled with 100 ml saline. Tumour visibility was assessed and compared with histopathology or CT and cystoscopy. RESULTS The procedure was successfully completed in 16 out of 19 patients. The reference standard revealed a bladder tumour in 16 out of 19 patients. Sensitivity of protocols 1 and 2 was 0.38 [95% confidence interval (CI), 0.16-0.64] compared with 0.63 (95% CI, 0.36-0.84) for protocols 3 and 4. CONCLUSION Flushing and subsequent retrograde filling of the bladder results in the highest rate of tumour visualization and quantification. Flushing alone is inferior. |
| Databáze: | OpenAIRE |
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