Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration

Autor:	William H. Gordon, Angelina Z Monroe, Jared S. Wood, Jeremy B. Morgan, R. Thomas Williamson, Gary E. Martin
Rok vydání:	2021
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Molecular Conformation 010402 general chemistry 01 natural sciences Catalysis Molecular conformation Materials Chemistry Cannabidiol beta Catenin 010405 organic chemistry Chemistry Metals and Alloys Wnt signaling pathway Cannabielsoin General Chemistry Nuclear magnetic resonance spectroscopy 0104 chemical sciences 3. Good health Surfaces Coatings and Films Electronic Optical and Magnetic Materials Wnt Proteins Biological target Catenin Ceramics and Composites Anisotropy
Zdroj:	Chemical Communications. 57:5658-5661
ISSN:	1364-548X 1359-7345
Popis:	In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8baae43a1125922374fa1cb038bd45a https://doi.org/10.1039/d1cc01971f Zobrazit plný text záznamu