Stimulation of the ovaries in women with breast cancer undergoing fertility preservation

Autor: R. van Golde, M. van Wely, Annelies M. E. Bos, D. Stoop, Y. Kopeika, Sabine C. Linn, C.B. Lambalk, J.P. de Bruin, Kathrin Fleischer, F. van der Veen, Leonie A. Louwe, Catharina C. M. Beerendonk, I. Schipper, Mariëtte Goddijn, N. Reddy, E. M. E. Balkenende, Jesper M. J. Smeenk, T. Dahhan, Roel Schats, Astrid E. P. Cantineau
Přispěvatelé: CCA - Cancer Treatment and quality of life, ACS - Atherosclerosis & ischemic syndromes, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Obstetrics & Gynecology, Gastroenterology & Hepatology, Other departments, Graduate School, Obstetrics and Gynaecology, Center for Reproductive Medicine, APH - Personalized Medicine, APH - Methodology, Surgical clinical sciences, Reproduction and Genetics, Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - R4 - Reproductive and Perinatal Medicine
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Oncology
GNRH AGONIST
Survival
Stimulation
OOCYTE DONORS
THERAPY
Body Mass Index
0302 clinical medicine
Breast cancer
PRACTICE GUIDELINE UPDATE
Recurrence
Pharmacology (medical)
Fertility preservation
AMERICAN-SOCIETY
Medicine(all)
Nitriles/therapeutic use
030219 obstetrics & reproductive medicine
Estradiol
Letrozole
Age Factors
General Medicine
YOUNG-WOMEN
Antineoplastic Agents/administration & dosage
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
ESTROGEN
Fertility Preservation/methods
HYPERSTIMULATION
Research Design
030220 oncology & carcinogenesis
Population study
Female
Ovarian stimulation
Triazoles/therapeutic use
Live birth
medicine.drug
Adult
medicine.medical_specialty
Adolescent
medicine.drug_class
Antineoplastic Agents
Breast Neoplasms
LETROZOLE
03 medical and health sciences
Young Adult
Breast Neoplasms/drug therapy
SDG 3 - Good Health and Well-being
Ovulation Induction
Internal medicine
Nitriles
Estrogens/blood
medicine
Journal Article
Humans
TAMOXIFEN
Gynecology
Cryopreservation
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
business.industry
Embryos
Follicle Stimulating Hormone/administration & dosage
Estrogens
Triazoles
Ovulation Induction/methods
medicine.disease
Tamoxifen/therapeutic use
Socioeconomic Factors
Estrogen
Oocytes
Follicle Stimulating Hormone
business
Tamoxifen
Zdroj: Contemporary Clinical Trials, 61, 96. Elsevier Inc.
Contemporary Clinical Trials, 61, 96-100
Contemporary Clinical Trials, 61, 96-100. ELSEVIER SCIENCE INC
Contemporary Clinical Trials, 61, 96-100. Elsevier Inc.
Contemporary clinical trials, 61, 96-100. Elsevier Inc.
Contemporary Clinical Trials, 61, pp. 96-100
Contemporary Clinical Trials, 61, 96-100. Elsevier Science
Dahhan, T, Balkenende, E M E, Beerendonk, C C M, Fleischer, K, Stoop, D, Bos, A M E, Lambalk, C B, Schats, R, van Golde, R J T, Schipper, I, Louwé, L A, Cantineau, A E P, Smeenk, J M J, de Bruin, J P, Reddy, N, Kopeika, Y, van der Veen, F, van Wely, M, Linn, S C & Goddijn, M 2017, ' Stimulation of the ovaries in women with breast cancer undergoing fertility preservation : Alternative versus standard stimulation protocols; the study protocol of the STIM-trial ', Contemporary Clinical Trials, vol. 61, pp. 96-100 . https://doi.org/10.1016/j.cct.2017.07.009
ISSN: 1551-7144
DOI: 10.1016/j.cct.2017.07.009
Popis: Item does not contain fulltext BACKGROUND: Chemotherapy for breast cancer may have a negative impact on reproductive function due to gonadotoxicity. Fertility preservation via banking of oocytes or embryos after ovarian stimulation with FSH can increase the likelihood of a future live birth. It has been hypothesized that elevated serum estrogen levels during ovarian stimulation may induce breast tumour growth. This has led to the use of alternative stimulation protocols with addition of tamoxifen or letrozole. The effectiveness of these stimulation protocols in terms of oocyte yield is unknown. METHODS/DESIGN: Randomized open-label trial comparing ovarian stimulation plus tamoxifen and ovarian stimulation plus letrozole with standard ovarian stimulation in the course of fertility preservation. The study population consists of women with breast cancer who opt for banking of oocytes or embryos, aged 18-43years at randomisation. Primary outcome is the number of oocytes retrieved at follicle aspiration. Secondary outcomes are number of mature oocytes retrieved, number of oocytes or embryos banked and peak E2 levels during ovarian stimulation. DISCUSSION: Concerning the lack of evidence on which stimulation protocol should be used in women with breast cancer and the growing demand for fertility preservation, there is an urgent need to undertake this study. By performing this study, we will be able to closely monitor the effects of various stimulation protocols in women with breast cancer and pave the way for long term follow up on the safety of this procedure in terms of breast cancer prognosis. TRIAL REGISTRATION: NTR4108.
Databáze: OpenAIRE
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