Photodynamic effect of palladium porphyrin derived from cashew nut shell liquid against promastigote forms of Leishmania braziliensis
| Autor: | Diego Lomonaco, Maria Jânia Teixeira, Nayane Maria de Amorim Lima, Thayllan Teixeira Bezerra, Glendo de Freitas Guimarães, Giuseppe Mele, Caio Herbertt Costa Braga, Naya Lúcia de Castro Rodrigues, Viviane Gomes Pereira Ribeiro, Selma Elaine Mazzetto, João Isaac Silva Miranda, Mayara Oliveira de Almeida |
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| Přispěvatelé: | Maria Amorim Lima, Nayane, Teixeira Bezerra, Thayllan, Oliveira Almeida, Mayara, Lucia de Castro Rodrigues, Naya, Herbertt Costa Braga, Caio, Isaac Silva Miranda, João, Gomes Pereira Ribeiro, Viviane, de Freitas Guimarães, Glendo, Jania Teixeira, Maria, Lomonaco, Diego, Mele, Giuseppe Agostino, Elaine Mazzetto, Selma, Lima, Nayane Maria Amorima, Bezerra, Thayllan Teixeiraa, Almeida, Mayara Oliveiraa, Rodrigues, Naya Lúcia de Castrob, Braga, Caio Herbertt Costac, Miranda, João Isaac Silvac, Ribeiro, Viviane Gomes Pereirad, Guimarães, Glendo de Freitasc, Teixeira, Maria Jâniab, Lomonaco, Diegoa, Mele, Giuseppe, Mazzetto, Selma Elainea |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Leishmania braziliensi Porphyrins medicine.medical_treatment media_common.quotation_subject 030303 biophysics Biophysics Leishmaniasis Cutaneous Photodynamic therapy Dermatology Photosensitizing Agent Leishmania braziliensis 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cutaneous leishmaniasis medicine Humans Nuts Pharmacology (medical) Anacardium Viability assay Cutaneous leishmaniasi media_common Nut 0303 health sciences Photosensitizing Agents biology Singlet oxygen Leishmaniasis Cutaneou medicine.disease biology.organism_classification Porphyrin Combinatorial chemistry Oncology chemistry Metalloporphyrin Photochemotherapy Toxicity CNSL Palladium Human |
| Popis: | Cutaneous leishmaniasis (CL) is a neglected tropical disease (NTD), endemic mainly in low-income countries that lack adequate basic health care. The emergence of resistant parasites to pentavalent antimonials has led to the search for new treatments for CL. Photodynamic therapy (PDT) is a promising non-invasive and less toxic alternative for the treatment of CL. The present work describes the synthesis, characterization and photodynamic effect against CL of a new metalloporphyrin Pd (II) meso-tetra[4-(2-(3-n-pentadecylphenoxy)ethoxy]phenylporphyrin (PdP) derived from the cashew nut shell liquid (CNSL). The PdP complex presented a singlet oxygen quantum yield of 0.49, favoring a type II photochemical reaction. The results of the photodynamic experiment carried out with PdP on the promastigote forms of Leishmania braziliensis indicated a mortality percentage of 70 % of the cells when compared to the control after exposure to blue light (λ = 420 nm). Besides this, the metalloporphyrin PdP did not show considerable toxicity to macrophages, indicating the cell viability of the compound. Therefore, this metalloporphyrin derived from biomass represents an interesting alternative as a potential therapeutic drug for the treatment of CL through PDT, especially for patients with intolerance to the chemotherapeutic drugs currently available. |
| Databáze: | OpenAIRE |
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