Biotherapeutic Nanoparticles of Poly(Ferulic Acid) Delivering Doxorubicin for Cancer Therapy
| Autor: | Yinghao Zheng, Xinru You, Liying Wang, Jun Wu, Long Chen, Shuyu Guan, Jun Huang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Coumaric Acids
Biocompatibility 0206 medical engineering Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology Pharmacology Ferulic acid chemistry.chemical_compound Drug Delivery Systems In vivo Neoplasms Tumor Microenvironment medicine Humans General Materials Science Doxorubicin Drug Carriers technology industry and agriculture 021001 nanoscience & nanotechnology 020601 biomedical engineering chemistry Drug delivery Toxicity Nanoparticles Nanocarriers 0210 nano-technology Drug carrier medicine.drug |
| Zdroj: | Journal of Biomedical Nanotechnology. 15:1734-1743 |
| ISSN: | 1550-7033 |
| DOI: | 10.1166/jbn.2019.2798 |
| Popis: | Chemotherapy drugs have been known as the mainstay of cancer treatment; however, they have inevitable side effects when used in isolation. Drug-loaded nanosystems represent a breakthrough drug delivery platform that enhances the treatment index of chemotherapy in cancer treatment; further, it compensates for the deficiency of body toxicity and significantly enhances antitumor effects. Given that designing biosafe nanodrugs requires nontoxicity of carriers, novel polymers, synthesized from natural products, with good biocompatibility and biodegradation are the preferred drug carriers. Ferulic acid (FA) derived from plants can be chemically modified to form poly(ferulic acid) (PFA) with reassuring biosafety. PFA-loading doxorubicin (DOX) was properly self-assembled into stable PFA@DOX nanoparticles (NPs), which released payloads continuously under slightly acidic conditions in vitro, ensuring effective drug delivery in acidic tumor microenvironments. In vivo antitumor therapy showed that the PFA nanocarriers could promote accumulation and retention at the tumor site for superior tumor suppression, while the PFA@DOX NPs reduced the physical toxicity of free DOX, thereby, improving safety. Therefore, such drug-loaded NPs can exert considerable influence over an antitumor action for potential clinical translation in the future. |
| Databáze: | OpenAIRE |
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